PREMIUM

Test4Cancer® PREMIUM is our most comprehensive test. Which includes most genes associated with both  common and rare hereditary cancer syndromes and for which there are medical management recommendations. The most common hereditary cancer syndromes are Hereditary breast and ovarian cancer (HBOC) and Hereditary colorectal cancer (Lynch syndrome).

In addition to the common hereditary syndromes there are several other, more rare hereditary cancer syndromes.

Genes: APC, ATM, BAP1, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDKN2A, CHEK2, DICER1, EPCAM, FH, FLCN, MAX, MEN1, MLH1, MSH2, MSH6, MUTYH, NF1, NF2, PALB2, PMS2, PTEN, RAD51C, RAD51D, RB1, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCB1, STK11, TMEM127, TP53, TSC1, TSC2, VHL, WT1

Who is this test suitable for?

Test4Cancer® PREMIUM is for those who seek a comprehensive assessment of their hereditary cancer risk, including common and rare hereditary cancer syndromes or those with a family history of cancer that is not typical of any of the more common hereditary cancer syndromes (such as HBOC or Lynch syndrome).

The likelihood of hereditary cancer is increased if you or a close relative1 have had:

  • Cancer at a young age
  • A rare type of cancer or several rare cancer types

Or if several relatives have had:

  • The same or related forms of rare cancer types

Some examples of rare hereditary cancer syndromes and their corresponding genetically related cancer types are as follows:

  • Skin melanoma and pancreatic cancer in the same family or individual could be a sign of familial melanoma
  • Diffuse gastric cancer and lobular breast cancer in the same family or individual could be a sign of Hereditary diffuse gastric cancer
  • Breast cancer, colorectal cancer, and gynecological cancer in the same family or individual could be a sign of Peutz-Jeghers syndrome (PJS)
  • Kidney cancer, vascular tumors in the cerebellum, brainstem, or spinal cord, and retina cancer in the same family or individual could be a sign of Von Hippel-Lindau syndrome (VHL)

Note that not all cancers need to be present in the family to suspect hereditary cancer and that the absence of a family history does not rule out the possibility hereditary cancer

What does a positive PREMIUM Test mean for my cancer risk?

Women

Women who’s Test4Cancer® PREMIUM test is positive have an increased lifetime risk for one or more cancers as compared to the average woman, including but not limited to:

Breast Cancer

Ovarian cancer

Uterine (endometrial) cancer

Colorectal cancer

Stomach cancer

Pancreatic cancer

Melanoma cancer

Brain cancer

Kidney cancer

Sarcoma

Thyroid cancer

Men

Men who’s Test4Cancer® PREMIUM test is positive have an increased lifetime risk for one or more cancers as compared to the average man, including but not limited to:

Prostate cancer

Colorectal cancer

Stomach cancer

Pancreatic cancer

Melanoma cancer

Brain cancer

Kidney cancer

Sarcoma

Thyroid cancer

How can I manage my risk?

Healthy carriers can take action to reduce their risk of developing cancer or to detect cancer early for a better prognosis. Which actions to take, at what age, and with which frequency varies depending on family history and which gene is varied. Here are some examples of risk reducing measures if testing positive for one of the genes included in Test4Cancer® PREMIUM:

Common hereditary cancer syndromes

  • Colonoscopy screening for hereditary colorectal cancer
  • Additional mammography and/or MRI of the breasts – or surgical removal of the breasts – for hereditary breast cancer
  • Surgical removal of the ovaries and fallopian tubes for hereditary ovarian cancer
  • PSA testing and palpation for hereditary prostate cancer

Rare hereditary cancer syndromes

  • Yearly skin exams as well as MRI of the pancreas for Familial melanoma
  • Gastroscopy or surgical removal of the stomach for hereditary for Hereditary diffuse gastric cancer
  • MRI and ultrasound of the kidneys for hereditary kidney cancer

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